Research in my lab focuses on five main research areas in hearing and deafness. First, we are interested in the changes in auditory perception and the electrophysiological changes that occur when the inner hair cells are selectively destroyed by carboplatin, a commonly used anti-cancer drug. Second, we are interested in the biological mechanisms that cause the sensory hair cells and neurons in the inner ear to die from exposure to ototoxic drugs (e.g., gentamicin, cisplatin) and acoustic overstimulation. Third, we are interested in identify therapeutic compounds that can protect or rescue the sensory hair cells or neurons from the damage caused by ototoxic drugs and high level noise exposure. Four, we are interested in using brain imaging techniques such as PET and fMRI to identify the functional changes that occur in the central auditory pathway following sensorineural hearing loss. Fifth, we are interested in identifying the biological mechanisms that give rise to the phantom sound of tinnitus and to identify drugs that can suppress tinnitus.
• Post-Doc Upstate Medical Center, 1976, Auditory Physiology
• Ph.D. Syracuse University, 1975, Experimental Psychology
• BS North Dakota State Univ., 1968, Psychology
• Professor, University at Buffalo; Dept. Communicative Disorders and Sciences
• Assistant Professor, U. Texas at Dallas, 1980-1984
• Associate Professor, U. Texas at Dallas, 1984-1987
• Hearing Research, 1993-present
• Audiology and Neuro-Otology, 1995-present
• International Tinnitus Journal, 1997-present
• Noise & Health, 1998-present
• Chinese Journal of Otolaryngology, editorial board, 1999-present
• American Academy of Audiology 1999-present
• Chinese Journal of Otorhinolaryngology of Integrated Traditional and Western Medicine, 2001-present
• Journal of Audiological Medicine and Sciences Related to Communicative Disorders, 2005-present
• Chinese Journal of Otolaryngology, 2003-present
• Iranian Journal of Audiology, 2002-present
• Medical Advisory Board of the Martha Entenmann Tinnitus Research Center
• Member, American Tinnitus Association Scientific Advisory Committee (SAC), 2001-present
• Chair, American Tinnitus Association Scientific Advisory Committee, 2004-present
• International Advisory Board, University College of London Centre for Auditory Research
• Faculty of 1000-Most interesting papers published in biology based on recommendations of over 1400 selected leading scientists (Jan. 2003). He, D.Z., Beisel, K.W., Chen, L., Ding, D.L., Jia, S., Fritzsch, B., Salvi, R. 2003. Chick hair cells do not exhibit voltage-dependent somatic motility. J Physiol 546, 511-20.
• Chancellors’s Award, State University of New York, 2003
• University at Buffalo Product Development Fund Award, 2004, SykofizX Software Application
Coling, D.E., Ding, D., Young, R., Lis, M., Stofko, E., Blumenthal, K.M., Salvi, R.J. 2007. Proteomic analysis of cisplatin-induced cochlear damage: Methods and early changes in protein expression. Hear Res 226, 140-56.
Chen, L., Sun, W., Salvi, R.J. 2006. Effects of nimodipine, an L-type calcium channel antagonist, on the chicken's cochlear potentials. Hear Res 221, 82-90.
Ding, D., Seigel, G., Salvi, R. 2006. Migration of R28 retinal precursor cells into cochlear and vestibular organs. J. Otology (China) 1, 51-56.
Ding, D., Jiang, H., Wang, P., Salvi, R. 2006 on line. Cell death after co-administration of cisplatin and ethacrynic acid Hear. Res.
Lobarinas, E., Yang, G., Sun, W., Ding, D., Mirza, N., Dalby-Brown, W., Hilczmayer, E., Fitzgerald, S., Zhang, L., Salvi, R. 2006. Salicylate- and quinine-induced tinnitus and effects of memantine. Acta oto-laryngologica, 13-9.
Willott, J.F., Vandenbosche, J., Shimizu, T., Ding, D.L., Salvi, R. 2006. Effects of exposing gonadectomized and intact C57BL/6J mice to a high-frequency augmented acoustic environment: Auditory brainstem response thresholds and cytocochleograms. Hear Res.
Yang, G., Lobarinas, E., Zhang, L., Turner, J., Stolzberg, D., Salvi, R., Sun, W. 2006 on line. Salicylate induced tinnitus: Behavioral measures and neural activity in auditory cortex of awake rats. Hear Res.
Corbacella, E., Lanzoni, I., Ding, D., Previati, M., Salvi, R. 2004. Minocycline attenuates gentamicin induced hair cell loss in neonatal cochlear cultures. Hear Res 197, 11-18.
Ding, D., Stracher, A., Salvi, R.J. 2002. Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity. Hear Res 164, 115-26.
Reyes, S., Salvi, R., Burkard, R., Coad, M., Wack, D., Galantowicz, P., Lockwood, A. 2002. Brain imaging of the effects of lidocaine on tinnitus. Hear Res 171, 43.
Sun, W., Salvi, R.J. 2001. Dopamine modulates sodium currents in cochlear spiral ganglion neurons. Neuroreport 12, 803-807.
Wang, J., Ding, D., Salvi, R.J. 2002. Functional reorganization in chinchilla inferior colliculus associated with chronic and acute cochlear damage. Hear Res 168, 238-49.
Zhang, M., Ding, D., Salvi, R. 2002. Expression of heregulin and ErbB/Her receptors in adult chinchilla cochlear and vestibular sensory epithelium. Hear Res 169, 56-68.
CDS 487, Psychoacoustic Science
CDS428/523, Neural Basis of Communication
• Member, Executive Committee, Communicative Disorders & Sciences, U. at Buffalo, 2006-present.
• Director, Center for Hearing & Deafness, 2003-present
• Member, Faculty Senate Research & Creative Activity Committee 1997-2001, 2003-2004
• Review Committee of VP for Research to Evaluate Lab Animal Facility Directors (March 2007)
• Task Force, Infrastructure, Heatlh and wellness across the lifespan, 2007
• Ad hoc reviewer, Royal National Institute for the Deaf, England, 2002.
• Ad hoc reviewer, NIH CDRC, June 2002
• Ad hoc reviewer, NIH CDRC, July 2003
• Ad hoc reviewer, NIH CDRC, R03 grant applications, June 2004.
• Chair, Scientific Advisory Committee, American Tinnitus Foundation, June 2004-present.
• Ad hoc reviewer, NIH CDRC, R01 grant applications, October, 2004
• Ad hos revierer, Raine Medical Research Foundation, U. of Western Australia, Australia, August, 2006.